HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → (R)-2-{4-[2-hydroxy-3-(3-isoxazolo[5,4-b]pyridin-3-yl-phenoxy)-propyl]-piperazin-1-yl}-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | (R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine | HCID 58928270 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | N-(2-Cyanophenyl)piperazine | HCID 2735875 | — |
| Product | (R)-2-{4-[2-hydroxy-3-(3-isoxazolo[5,4-b]pyridin-3-yl-phenoxy)-propyl]-piperazin-1-yl}-benzonitrile | HCID 58928309 | — |
Reaction Steps
The title compound is prepared from a mixture of (R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine in dimethylformamide and ethanol and 1-(2-cyanophenyl)piperazine in ethanol essentially as described above in Example 102. Purity by LC/MS=100%, [M+H]+=456.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253165B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-6749c9daabaa4597bffbaea5573e8e5d |
| Source note | uspto-grants-2007_08 |