3-(4-Piperidyl)-6-fluoro-1,2-benzisoxazole → (R)-1-[4-(6-fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-3-(3-isoxazolo[5,4-b]pyridin-3-yl-phenoxy)-propan-2-ol

Participants

Reaction Steps

The title compound is prepared from a mixture of (R)-3-(3-oxiranylmethoxy-phenyl)-isoxazolo[5,4-b]pyridine in dimethylformamide and ethanol and 6-fluoro-3-piperidine-4-yl-benzo[d]isoxazole (Table No. 1, SM 8) in ethanol essentially as described above in Example 102. Purity by LC/MS=100%, [M+H]+=489.

Provenance & Evidence