Benzenemethanamine, 3,4-dichloro- → HCID 58928290, compound

Participants

Reaction Steps

Combine (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole (29) (250 mg, 0.86 mmol), 3,4-dichlorobenzylamine (617 mg, 3.50 mmol), ethanol (4.0 ml) and heat (˜80° C.) for 16 hours. Cool reaction at 0° C. for 1 h. Collect the solid product and wash with cold ethanol several times. Dry the solid at (50° C./0.5 mm Hg) overnight to give 313 mg (77% yield) of the title compound. Purity by LC/MS=96%, [M+H]+=461.

Provenance & Evidence