2-(Trifluoromethyl)benzylamine → HCID 58928300, compound

HRID 852196Notes

Reaction equation

HRID 852196 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.[F:22][C:23]([F:33])([F:32])[C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26][NH2:27]>C(O)C>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]([OH:18])[CH2:19][NH:27][CH2:26][C:25]4[CH:28]=[CH:29][CH:30]=[CH:31][C:24]=4[C:23]([F:22])([F:32])[F:33])=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 764472-(Trifluoromethyl)benzylamineHCID 58928269(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 58928300HCID 58928300, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound is prepared from (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole, 2-(trifluoromethyl)benzylamine, and ethanol essentially as described above in Example 112. Purity by LC/MS=96%, [M+H]+=461.

Sources & evidence

ORD record
ord-004360b7d78e440c9e81200fe7043bb1
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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