4-(Trifluoromethyl)benzylamine → HCID 58928257, compound

HRID 852197Notes

Reaction equation

HRID 852197 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:14]=[CH:13][C:12]([O:15][CH2:16][C@H:17]4[CH2:19][O:18]4)=[CH:11][CH:10]=3)=[N:7][O:8][C:4]=2[CH:3]=1.[F:22][C:23]([F:33])([F:32])[C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1>C(O)C>[F:1][C:2]1[CH:21]=[CH:20][C:5]2[C:6]([C:9]3[CH:10]=[CH:11][C:12]([O:15][CH2:16][C@H:17]([OH:18])[CH2:19][NH:29][CH2:28][C:27]4[CH:26]=[CH:25][C:24]([C:23]([F:22])([F:32])[F:33])=[CH:31][CH:30]=4)=[CH:13][CH:14]=3)=[N:7][O:8][C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 768044-(Trifluoromethyl)benzylamineHCID 58928269(R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole

Product 1

HCID 58928257HCID 58928257, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound is prepared from (R)-6-fluoro-3-(4-oxiranylmethoxy-phenyl)-benzo[d]isoxazole, 4-(trifluoromethyl)benzylamine, and ethanol essentially as described above in Example 112. Purity by LC/MS=95%, [M+H]+=461.

Sources & evidence

ORD record
ord-b46aa43a2bb94c8c94ce7454b74a271e
Source dataset
uspto-grants-2007_08
Patent number
US07253165B2

Reaction notes

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