反应详情

温度

100 °C

A mixture of 2-amino-3-benzyloxypyridine (2.7 g, 13.5 mmol) and 2-bromo-4-methyl-4-nitropentanal (3.0 g, 13.5 mmol) in ethanol (20 ml) is heated at 100° C. overnight. The solvent is removed under reduced pressure and the residue is treated with saturated aqueous NaHCO3 solution. The aqueous mixture is extracted two times with ethyl acetate. The combined organic extracts are dried over magnesium sulfate and concentrated in vacuo. The residue is chromatographed (silica gel, dichloromethane/ethanol 9:1) to give 2.83 g of 3-(2-methyl-2-nitropropyl)-8-(phenylmethoxy)imidazo[1,2-a]pyridine (64%).

1. customThe solvent is removed under reduced pressure
2. additionthe residue is treated with saturated aqueous NaHCO3 solution
3. extractionThe aqueous mixture is extracted two times with ethyl acetate
4. dry with materialThe combined organic extracts are dried over magnesium sulfate
5. concentrationconcentrated in vacuo
6. customThe residue is chromatographed (silica gel, dichloromethane/ethanol 9:1)