Trifluoroacetic acid → HCID 69378472, compound

Participants

Reaction Steps

A solution of (S)-2-tert-butoxycarbonylamino-3-[4-([2,6]naphthyridin-1-yloxy)phenyl]propionic acid methyl ester (271 mg, 0.64 mmol) in dichloromethane (7.5 ml) was treated with trifluoroacetic acid (7.5 ml) and stirred at room temperature for 2 h. The volatiles were removed in vacuo and the residue was partitioned between EtOAc (60 ml) and saturated aqueous NaHCO3 (25 ml). The phases were separated and the aqueous layer re-extracted with EtOAc (3×25 ml). The combined organic extracts were dried (MgSO4) and evaporated in vacuo to afford the title compound (206 mg, 100%) as an oil that was used in the next step without further purification.

Provenance & Evidence