Triethylamine → HCID 87801558, compound

Participants

Reaction Steps

(S)-2-Amino-3-{4-[(3,5-dichloropyridine-4-carbonyl)amino]phenyl}propionic acid methyl ester (0.25 g, 0.62 mmol) was added at room temperature to a tetrahydrofuran solution (3 ml) of thiocarbonyidiimidazol (0.12, 0.68 mmol) and triethylamine (0.062, 0.62 mmol) and stirred for 2 h. Next, the solvent was removed under reduced pressure and compound from Preparation 11 was added in acetonitrile (3 ml) and stirred at 80° C. for 3 h. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (Hexane:AcOEt, 1:1) to yield the title compound(0.23 g, 62%) as a yellow solid.

Provenance & Evidence