p-Fluoronitrobenzene → 4-(2-Carboxymethoxyphenoxy)nitrobenzene

HRID 852262Notes

Reaction equation

HRID 852262 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[OH:11][C:12]1[CH:22]=[CH:21][CH:20]=[CH:19][C:13]=1[O:14][CH2:15][C:16]([OH:18])=[O:17].CC(C)([O-])C.[K+].CC(N(C)C)=O>>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([O:11][C:12]2[CH:22]=[CH:21][CH:20]=[CH:19][C:13]=2[O:14][CH2:15][C:16]([OH:18])=[O:17])=[CH:3][CH:4]=1)([O-:10])=[O:9]

Participants

4

Reactant 3

HCID 9590p-FluoronitrobenzeneHCID 22783(o-Hydroxyphenoxy)acetic acidHCID 131726543potassium t-butoxide DMA

Product 1

HCID 220485044-(2-Carboxymethoxyphenoxy)nitrobenzene

Procedure

4-(fluoro)nitrobenzene was reacted with 2-(2-hydroxyphenoxy)acetic acid in the presence of potassium t-butoxide/DMA at 150° C. for 2 hrs to give 2-[(2-(4-nitrophenoxy)phenoxy]acetic acid. The product was purified by chromatography.

Sources & evidence

ORD record
ord-eaacba32a4c84518a2fe7125bbf89848
Source dataset
uspto-grants-2007_08
Patent number
US07253184B2

Reaction notes

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