1-Bromo-3-chloropropane → HCID 10460436, compound

Participants

Reaction Steps

The desired compound was synthesized from N-(4-fluorobenzyl)-2-(4-isobutoxyphenyl)-N-piperidin-4-yl-acetamide 103NLS56 (107 mg, 0.27 mmol), 2-pyrrolidone and 1-bromo-3-chloropropane using the same method as for synthesis of 98AF73-64. Purification of the product by silica gel column chromatography, eluting with a stepwise gradient of 4–8% methanol in dichloromethane; afforded the title compound (15 mg, 11%).

Provenance & Evidence