Ethylamine → HCID 60090601, compound

HRID 852308Notes

Reaction equation

HRID 852308 reaction equation
[OH:1][CH2:2][C@@H:3]([NH:10][C:11]([C:13]1[NH:14][CH:15]=[C:16]([C:18]2[C:23]([CH3:24])=[CH:22][N:21]=[C:20](S(CCC)(=O)=O)[N:19]=2)[CH:17]=1)=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:31]([NH2:33])[CH3:32]>CS(C)=O>[OH:1][CH2:2][C@@H:3]([NH:10][C:11]([C:13]1[NH:14][CH:15]=[C:16]([C:18]2[C:23]([CH3:24])=[CH:22][N:21]=[C:20]([NH:33][CH2:31][CH3:32])[N:19]=2)[CH:17]=1)=[O:12])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 10320380HCID 10320380, compound

Product 1

HCID 60090601HCID 60090601, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
130 °C

Procedure

To a solution of 4-[5-methyl-2-(propane-1-sulfonyl)-pyrimidin-4-yl]-1H-pyrrole-2-carboxylic acid (2-hydroxy-1-(S)-phenyl-ethyl)-amide (47 μmol, 20 mg) in DMSO (1 mL) was added ethylamine (0.5 mmol, 150 μL). The mixture was heated at 130° C. for 24 hours to afford the title compound. LC/MS(m/z) 366.2 (M+1); HPLC Method B, Rt=4.2 minutes; 1H NMR consistent with the structure.

Sources & evidence

ORD record
ord-f83f6c81604c46bc902f663f4280ccaa
Source dataset
uspto-grants-2007_08
Patent number
US07253187B2

Reaction notes

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