Phosphorus oxychloride → HCID 17938141, compound

Participants

Reaction Steps

35 ml of POCl3 and a small amount of NH4Cl were added to 2.0 g of 1-ethyl-4-(4-fluorophenyl)-5-(4-pyridyl)imidazol-2-one, and the reaction mixture was heated under reflux for 9 h. After cooling, most of the excess POCl3 was distilled off, and distilled water was carefully added to the residue. The mixture was neutralized using 20% strength NaOH, resulting in the precipitation of the title compound. The precipitate was filtered off and dried over P2O5 under reduced pressure. Yield: 81%.

Provenance & Evidence