Isophthalonitrile → 3-(2H-tetrazol-5-yl)benzonitrile

HRID 852320Notes

Reaction equation

HRID 852320 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[N:10][NH:11][N:12]=2)[CH:5]=[CH:6][CH:7]=1.[C:13](C1C=CC=C(C#N)C=1)#[N:14]>>[N:12]1[NH:11][N:10]=[N:9][C:8]=1[C:4]1[CH:3]=[C:2]([CH:7]=[CH:6][CH:5]=1)[C:13]#[N:14]

Participants

3

Reactant 2

HCID 12276IsophthalonitrileHCID 40730565-(3-bromophenyl)-1H-1,2,3,4-tetrazole

Product 1

HCID 113557393-(2H-tetrazol-5-yl)benzonitrile

Procedure

Following the procedure in COMPOUND 3 for the synthesis of 5-(3-bromophenyl)-2H-tetrazole, 1,3-dicyanobenzene (2.0 g, 15.63 mmol) was employed to obtain 3-(2H-tetrazol-5-yl)benzonitrile.

Sources & evidence

ORD record
ord-56decdbd17f94a68870a83620377d3ee
Source dataset
uspto-grants-2007_08
Patent number
US07253190B2

Reaction notes

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