HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 25151661, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Acetaldehyde ammonia | HCID 522583 | — |
| Reactant | N-{[(5S)-3-{4-[3-(Bromomethyl)-2-oxopyridin-1(2H)-yl]-3-methylphenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl}-5-chlorothiophene-2-carboxamide | HCID 59410175 | — |
| Product | HCID 25151661 | HCID 25151661 | — |
Reaction Steps
At −10° C., 38 mg (0.63 mmol) of aminoethanol are added to a solution of 56 mg (0.11 mmol) of the compound from Example 11A in 1 ml of DMF. After 30 min at −10° C., the mixture is added to water and then extracted three times with ethyl acetate. The organic phases are combined and then freed from the solvent under reduced pressure. The product is purified by preparative HPLC using an acetonitrile/water mixture. This gives 14.5 mg (26% of theory) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846934B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-e5c41719a1074ce286fce892844580d6 |
| Source note | uspto-grants-2014_09 |