Lithium Hydroxide → HCID 11568655, compound

Participants

Reaction Steps

0.105 g (0.22 mmol) of the above prepared 2-methyl-2-{2-methyl-4-[5-(4-trifluoromethoxy-phenyl)-pent-4-ynylsulfanyl]-phenoxy}-propionic acid ethyl ester was dissolved in 4 ml of THF/EtOH (1:1), treated at 0° C. with 0.66 ml (0.66 mmol) of 1N LiOH, and kept at ambient temperature for 22 h. The reaction mixture was taken up in ether and washed with aqueous 10% KHSO4 solution and aqueous 10% NaCl solution. The water phases were extracted with ether (two times). The organic phase was dried (Na2SO4) and evaporated. The crude product was precipitated in pentane (RT to 4° C.) and decanted to give 28 mg of the title compound as colorless oil.

Provenance & Evidence