Methanesulfonyl chloride → Methanesulfonic acid 5-(3-trifluoromethoxy-phenyl)-pent-4-ynyl ester

HRID 852362Notes

Reaction equation

[F:1][C:2]([F:17])([F:16])[O:3][C:4]1[CH:5]=[C:6]([C:10]#[C:11][CH2:12][CH2:13][CH2:14][OH:15])[CH:7]=[CH:8][CH:9]=1.[CH3:18][S:19](Cl)(=[O:21])=[O:20]>>[F:1][C:2]([F:16])([F:17])[O:3][C:4]1[CH:5]=[C:6]([C:10]#[C:11][CH2:12][CH2:13][CH2:14][O:15][S:19]([CH3:18])(=[O:21])=[O:20])[CH:7]=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 688216934-Pentyn-1-ol, 5-[3-(trifluoromethoxy)phenyl]-

Product 1

HCID 86602537Methanesulfonic acid 5-(3-trifluoromethoxy-phenyl)-pent-4-ynyl ester

Procedure

In analogy to the procedure described in example 1G], 5-(3-trifluoromethoxy-phenyl)-pent-4-yn-1-ol and methanesulfonyl chloride gave the title compound as a light brown oil.

Sources & evidence

ORD record: ord-5926ae070d3549979e31223d349fa216
Source dataset: uspto-grants-2007_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07253192B2

Reaction notes

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