HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → {2-Methyl-4-[3-(4-trifluoromethyl-phenyl)-prop-2-ynylsulfanyl]-phenoxy}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {2-Methyl-4-[3-(4-trifluoromethyl-phenyl)-prop-2-ynylsulfanyl]-phenoxy}-acetic acid tert-butyl ester | HCID 69458063 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | {2-Methyl-4-[3-(4-trifluoromethyl-phenyl)-prop-2-ynylsulfanyl]-phenoxy}-acetic acid | HCID 11696577 | — |
Reaction Steps
A solution of 75 mg (1.7 mmol) of the above prepared {2-methyl-4-[3-(4-trifluoromethyl-phenyl)-prop-2-ynylsulfanyl]-phenoxy}-acetic acid tert-butyl ester in 2 ml dichloromethane was treated at 0° C. with 0.4 ml TFA and stirred at RT for 3 h. The reaction was evaporated, dissolved in toluene and evaporated again (two times). Purification by flash chromatography on SiO2 with a gradient of CH2Cl2/MeOH (98:2 to 9:1) yielded 30 mg of the title compound as white crystals, mp. 130-131° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253192B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-d8f43f492d204df3a52bd368a7d1eae5 |
| Source note | uspto-grants-2007_08 |