Benzene, 1-iodo-4-(trifluoromethyl)- → 2-Methyl-2-{2-methyl-4-[5-(4-trifluoromethyl-phenyl)-pent-4-ynyloxy]-phenoxy}-propionic acid ethyl ester

HRID 852376Notes

Reaction equation

HRID 852376 reaction equation
[CH2:1]([O:3][C:4](=[O:22])[C:5]([CH3:21])([O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][C:18]#[CH:19])=[CH:10][C:9]=1[CH3:20])[CH3:6])[CH3:2].I[C:24]1[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=1>>[CH2:1]([O:3][C:4](=[O:22])[C:5]([CH3:21])([O:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][CH2:17][C:18]#[C:19][C:24]2[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=2)=[CH:10][C:9]=1[CH3:20])[CH3:6])[CH3:2]

Participants

3

Reactant 2

HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 866025402-Methyl-2-(2-methyl-4-pent-4-ynyloxy-phenoxy)-propionic acid ethyl ester

Product 1

HCID 694589932-Methyl-2-{2-methyl-4-[5-(4-trifluoromethyl-phenyl)-pent-4-ynyloxy]-phenoxy}-propionic acid ethyl ester

Procedure

In analogy to the procedure described in example 13B], 2-methyl-2-(2-methyl-4-pent-4-ynyloxy-phenoxy)-propionic acid ethyl ester (example 13A]) and 1-iodo-4-trifluoromethyl-benzene gave the title compound as a light yellow viscous oil.

Sources & evidence

ORD record
ord-ce01b2fe7acb4864b0a6f867331152a0
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

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