Benzene, 1-iodo-3-(trifluoromethyl)- → HCID 68454827, compound

HRID 852386Notes

Reaction equation

HRID 852386 reaction equation
I[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[CH:3]=1.[CH2:12]([OH:17])[CH2:13][CH2:14][C:15]#[CH:16]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[F:9][C:8]([F:11])([F:10])[C:4]1[CH:3]=[C:2]([C:16]#[C:15][CH2:14][CH2:13][CH2:12][OH:17])[CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 67868Benzene, 1-iodo-3-(trifluoromethyl)-HCID 793464-Pentyn-1-ol

Product 1

HCID 68454827HCID 68454827, compound

Reagents, catalysts & solvents 1

HCID 178418397HCID 178418397, compoundCatalyst

Procedure

In analogy to the procedure described in example 1F], 1-iodo-3-trifluoromethyl-benzene, was reacted with 4-pentyn-1-ol in the presence of Pd(PPh3)4 and cuprous iodide to yield the title compound as brown oil.

Sources & evidence

ORD record
ord-a783a1a6e8b14ecf9b0206f574e68bfa
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

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