Ethyl 2-(4-hydroxy-2-methylphenoxy)-2-methylpropanoate → HCID 69457686, compound

HRID 852400Notes

Reaction equation

HRID 852400 reaction equation
[F:1][C:2]([F:18])([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][CH2:12][CH2:13][CH:14]([OH:16])[CH3:15])=[CH:6][CH:5]=1.[CH2:19]([O:21][C:22](=[O:35])[C:23]([O:26][C:27]1[CH:32]=[CH:31][C:30](O)=[CH:29][C:28]=1[CH3:34])([CH3:25])[CH3:24])[CH3:20]>>[CH2:19]([O:21][C:22](=[O:35])[C:23]([CH3:25])([O:26][C:27]1[CH:32]=[CH:31][C:30]([O:16][CH:14]([CH3:15])[CH2:13][CH2:12][C:11]#[C:10][C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:17])([F:18])[F:1])=[CH:9][CH:8]=2)=[CH:29][C:28]=1[CH3:34])[CH3:24])[CH3:20]

Participants

3

Reactant 2

HCID 16756990Ethyl 2-(4-hydroxy-2-methylphenoxy)-2-methylpropanoateHCID 68826125HCID 68826125, compound

Product 1

HCID 69457686HCID 69457686, compound

Procedure

In analogy to the procedure described in example 24A], rac-6-(4-trifluoromethoxy-phenyl)-hex-5-yn-2-ol (example 31E]) and 2-(4-hydroxy-2-methyl-phenoxy)-2-methyl-propionic acid ethyl ester (described in WO 02/092590) yielded the title compound as yellow oil.

Sources & evidence

ORD record
ord-b65bfd6a29064a1594d1f162b5ed8218
Source dataset
uspto-grants-2007_08
Patent number
US07253192B2

Reaction notes

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