Carbon Dioxide → HCID 68826125, compound

Participants

Reaction Conditions

Reaction Steps

Within 15 min was dropped 1.46 ml (1.2 M in toluene, 1.75 mmol) of DIBAL-H to a dry ice cooled (−30° C.) solution of 0.23 g (0.88 mmol) 6-(4-trifluoromethoxy-phenyl)-hex-5-yn-2-one in 4 ml of THF. The reaction was warmed up (0° C. for 1 h 10 min) and neutralized with aqueous 10% KHSO4 solution. The mixture was extracted with ether (three times), the organic phases were washed with a aqueous 10% NaCl solution, dried (Na2SO4) and evaporated to give 0.24 g of the title compound as light brown oil.

Provenance & Evidence