HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisobutylaluminum hydride → {1-[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutyl}-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisobutylaluminum hydride | HCID 14487 | — |
| Reactant | 1-[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutanecarboxylic acid ethyl ester | HCID 69458936 | — |
| Product | {1-[3-(4-Trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutyl}-methanol | HCID 69458280 | — |
Reaction Steps
In analogy to the procedure described in example 31E], reduction of 1-[3-(4-trifluoromethoxy-phenyl)-prop-2-ynyl]-cyclobutanecarboxylic acid ethyl ester with 3 equivalent of DIBAL-H (1.2 M solution in toluene) gave the title compound as yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253192B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-7cadb8b8acd44bf8b0cfdfdcdff4f6bd |
| Source note | uspto-grants-2007_08 |