N-[4-[4-(phenylmethyl)-1-piperazinyl]phenyl]-[1,1'-biphenyl]-2-carboxamide → N-[4-(1-piperazinyl)phenyl]-[1,1'-biphenyl]-2-carboxamide

Participants

Reaction Steps

A mixture of intermediate (9) (0.1 mole) in methanol (500 ml) was hydrogenated for two hours with palladium-on-carbon (10%) (10 g) as a catalyst. After uptake of hydrogen (1 equivalent), the catalyst was filtered off and the filtrate was evaporated. The residue was triturated in 2-propanol. The precipitate was filtered off and dried, yielding 29 g of N-[4-(1-piperazinyl)phenyl]-[1,1′-biphenyl]-2-carboxamide (intermediate 10, melting point 176° C.).

Provenance & Evidence