HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 10120773, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Benzeneacetic acid, alpha-bromo-, methyl ester | HCID 137806 | — |
| Reactant | 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-(piperazinyl)-phenyl]-amide | HCID 11201099 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10120773 | HCID 10120773 | 86.4% |
Reaction Steps
A mixture of intermediate (6) (0.023 mole) and Na2CO3 (0.023 mole) in DMF (150 ml) was stirred. Methyl α-bromo-α-phenylacetate (0.023 mole) was added dropwise. The mixture was stirred overnight. The solvent was evaporated. The residue was dissolved in DCM. The organic layer was separated, washed, dried, filtered and the solvent was evaporated. The residue was triturated in DIPE. The precipitate was filtered off and dried, yielding 11.4 g of methyl α-phenyl-4-[4-[[[4′-(trifluoromethyl)[1,1′-biphenyl]-2-yl]carbonyl]amino]phenyl]-1-piperazineacetate identified as compound No. 40 in the following table F-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253157B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-08b040e8535347a29d9c481ca8155512 |
| Source note | uspto-grants-2007_08 |