Ammonia → HCID 13468213, compound

HRID 852532Notes

Reaction equation

HRID 852532 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][S:6](Cl)(=[O:8])=[O:7].[NH3:10].C(Cl)[Cl:12]>>[Cl:12][CH:3]([CH3:2])[CH2:4][CH2:5][S:6]([NH2:10])(=[O:8])=[O:7]

Participants

4

Reactant 3

HCID 222AmmoniaHCID 6344DichloromethaneHCID 742124-Chlorobutane-1-sulphonyl chloride

Product 1

HCID 13468213HCID 13468213, compoundYield 88%

Procedure

To an ice-cooled solution of 4-chloro-1-butanesulfonyl chloride (D20) (43 g, 225 mmol, 1 equiv) in CH2Cl2 (350 ml) was slowly added aqueous ammonia solution (25%, 140 ml). The resulting mixture was stirred at room temperature for 16 h then concentrated in vacuo. The residue was diluted with AcOEt and washed with brine. The organic phase was dried over MgSO4 and concentrated in vacuo to give crude 3-chloro-1-butanesulfonamide (D21b) (31 g, 88%).

Workup

  1. concentrationthen concentrated in vacuo
  2. additionThe residue was diluted with AcOEt
  3. washwashed with brine
  4. dry with materialThe organic phase was dried over MgSO4
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-118480af9f5340d4a7920d5c75b443e0
Source dataset
uspto-grants-2007_08
Patent number
US07253198B2

Reaction notes

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