HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butanol → HCID 69359268, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | 1,3-Benzenedicarboxylic acid, 5-nitro-, 1-methyl ester | HCID 74776 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69359268 | HCID 69359268 | 85% |
Reaction Steps
A mixture of 5-nitro-isophthalic acid monomethyl ester (D77) (5.0 g, 22.2 mmol, 1 equiv), tert-BuOH (8.2 g, 111 mmol, 5 equiv), EDAC.HCl (4.8 g, 25 mmol, 1.1 equiv) and DMAP (205 mg, 1.68 mmol, 0.07 equiv) dissolved in CH2Cl2 (50 ml) was stirred for 1 h at room temperature The mixture was then diluted with CH2Cl2 (50 ml), washed with 2N aqueous HCl solution (50 ml) and saturated aqueous NaHCO3 solution (50 ml), dried over MgSO4 and concentrated in vacuo to give of 5-nitro-isophthalic acid 1-tert-butyl ester 3-methyl ester (D78) (5.3 g, 85%) as a pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253198B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-dc2bd95a805e42e799e1bc6f5a23f911 |
| Source note | uspto-grants-2007_08 |