Isobutylamine → HCID 28519069, compound

Participants

Reaction Steps

(S)-2-tert-butoxycarbonylamino-4-methylsulfanyl-butyric acid (D95) (2.0 g, 8.0 mmol, 1 equiv), EDAC.HCl (1.84 g, 9.6 mmol, 1.2 equiv), HOBT (1.47 g, 9.6 mmol, 1.2 equiv), 4-ethylmorpholine (1.76 g, 16 mmol, 2 equiv) and iso-butylamine (952 ml, 9.6 mmol, 1.2 equiv) in CH2Cl2 (10 ml) were stirred at room temperature for 16 h. The solution was concentrated in vacuo and the residue dissolved in AcOEt. The organic phase was washed with 2N aqueous HCl solution, saturated aqueous NaHCO3 solution and brine, dried over MgSO4 and concentrated in vacuo to give ((S)-1-isobutylcarbamoyl-3-methylsulfanyl-propyl)-carbamic acid tert-butyl ester (D96) (2.38 g, 98%) as a colourless oil.

Provenance & Evidence