反应详情

To a solution of 3-methylsulfanyl-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid (A1) (59 mg, 0.235 mmol, 1 equiv) in MeOH/H2O (3:1, 24 ml) was added oxone (578 mg, 0.94 mol, 4 equiv). The resulting mixture was stirred at room temperature for 50 min and then concentrated in vacuo. The residue was partitioned between AcOEt and H2O and the layers separated. The organic layer was washed with H2O and brine, dried over Na2SO4 and concentrated in vacuo to give a solid which was triturated with Et2O to give 3-methanesulfonyl-5-(2-oxo-pyrrolidin-1-yl)-benzoic acid (A5) (57 mg, 86%) as a white solid. [M+H]+=284.0, RT=2.05 min

1. concentrationconcentrated in vacuo
2. customThe residue was partitioned between AcOEt and H2O
3. customthe layers separated
4. washThe organic layer was washed with H2O and brine
5. dry with materialdried over Na2SO4
6. concentrationconcentrated in vacuo
7. customto give a solid which
8. customwas triturated with Et2O