4-Oxo-1-phenylcyclohexylamine hydrochloride → (RS)-N-(4-Oxo-1-phenylcyclohexyl)-alpha-methyl-alpha-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide

Participants

Reaction Steps

Prepared from (RS)-α-methyl-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid (Description 10) and 4-oxo-1-phenylcyclohexylamine hydrochloride (Description 3) according to the method of Description 11. 1H NMR (360 MHz, CDCl3) δ 7.81 (1H, s), 7.71 (2H, s), 7.35-7.27 (5H, m), 5.58 (1H, br s), 5.57-5.45 (1H, m), 5.09-5.03 (2H, m), 2.81-2.73 (2H, m), 2.66-2.60 (2H, m), 2.48-2.30 (6H, m), and 1.63 (3H, s).

Provenance & Evidence