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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 852697Generated: October 25, 2026

Ethyl 1-bromocyclobutanecarboxylate → 6-[(2,2,3,3-tetramethylcyclopropyl)amino]-5-thia-7-azaspiro[3.4]oct-6-en-8-one

https://huagongshe.com/reaction/852697

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 1-bromocyclobutanecarboxylateHCID 97595—
ReactantN-(2,2,3,3-tetramethylcyclopropyl)thioureaHCID 79006986—
Product6-[(2,2,3,3-tetramethylcyclopropyl)amino]-5-thia-7-azaspiro[3.4]oct-6-en-8-oneHCID 178428351—

Reaction Steps

Synthesis was performed from N-(2,2,3,3-tetramethylcyclopropyl)thiourea and ethyl 1-bromocyclobutanecarboxylate according to Method D.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07253196B2
Source datasetuspto-grants-2007_08
ORD IDord-4eee9b7f3e91406eaf1d86e9d7d3accc
Source noteuspto-grants-2007_08