HRID85283

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1=C(C#N)C(=C(C#N)C#N)OC1(C)C(F)(F)F

HCID22020292

未命名化合物

HCID86667575

未命名化合物

PRODUCTS

生成物

结构：CCCCN(CCCC)c1ccc(C=CC=CC=CC2=C(C#N)C(=C(C#N)C#N)OC2(C)C(F)(F)F)c(OC)c1

HCID86667576

未命名化合物

收率 82.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度: 50 °C

PROCEDURE

实验过程

To 5 ml of ethanol were added 130 mg (0.41 mmol) of 5-(4-dibutylamino-2-methoxyphenyl)-2,4-pentadienal and 115 mg (0.45 mmol) of 2-(3-cyano-4,5-dimethyl-5-trifluoromethyl-2(5H)-furanylidene) propanedinitrile, and the mixture was stirred with heating at 50° C. for 2 hours. The precipitate was separated by filtration and purified by silica gel column chromatography to give 187 mg of a greenish brown crystal (yield: 82.5%; mp: 168-172° C.)

WORKUP

后处理

customThe precipitate was separated by filtration
custompurified by silica gel column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e4d222539033433e94a48d109ee70486
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846955B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH2:1]([N:5]([CH2:20][CH2:21][CH2:22][CH3:23])[C:6]1[CH:11]=[CH:10][C:9]([CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=O)=[C:8]([O:18][CH3:19])[CH:7]=1)[CH2:2][CH2:3][CH3:4].[C:24]([C:26]1[C:27](=[C:37]([C:40]#[N:41])[C:38]#[N:39])[O:28][C:29]([CH3:36])([C:32]([F:35])([F:34])[F:33])[C:30]=1[CH3:31])#[N:25]>C(O)C>[CH2:1]([N:5]([CH2:20][CH2:21][CH2:22][CH3:23])[C:6]1[CH:11]=[CH:10][C:9]([CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=[CH:31][C:30]2[C:29]([CH3:36])([C:32]([F:35])([F:33])[F:34])[O:28][C:27](=[C:37]([C:40]#[N:41])[C:38]#[N:39])[C:26]=2[C:24]#[N:25])=[C:8]([O:18][CH3:19])[CH:7]=1)[CH2:2][CH2:3][CH3:4]