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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 852834Generated: October 30, 2026

Trifluoroacetic acid → HCID 131723653, compound

https://huagongshe.com/reaction/852834

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 131723651HCID 131723651—
SolventChloroformHCID 6212—
ProductHCID 131723653HCID 131723653—

Reaction Steps

Morpholino-Ser(OAloc) was prepared from Ser(OtBu)-OtBu. Reaction of Ser(OtBu)-OtBu with 4-morpholinecarbonyl chloride in pyridine yielded morpholino-Ser(OtBu)-OtBu. Morpholino-Ser(OtBu)-OtBu was hydrolyzed with TFA to yield morpholino-Ser. Esterification of morpholino-Ser with isobutylene in the presence of a catalytic amount of H2SO4 afforded morpholino-Ser-OtBu. Reaction of morpholino-Ser-OtBu with allyl 1-benzotriazolyl carbonate yielded morpholino-Ser(OAloc)-OtBu. Morpholino-Ser(OAloc)-OtBu was hydrolyzed with TFA in CHCl3 (1:1) to yield morpholino-Ser(OAloc).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07253207B2
Source datasetuspto-grants-2007_08
ORD IDord-80d5cd1f58d74dce8e7d414a43855102
Source noteuspto-grants-2007_08