Potassium sodium tartarate → HCID 86591135, compound

Participants

Reaction Steps

A suspension of LiAlH4 (143 mg, 3.76 mmol) in THF (5 mL) was added over 10 min to a solution of [2-(1-benzyl-2-methyl-2,3-dihydro-1H-indol-3-yl)-1-(methoxy-methyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester (2 g, 4.32 mmol) in THF (35 mL) at −20° C. The reduction was complete in 15 min (silica gel, 50% EtOAc/petroleum ether, Rf 0.76). Saturated sodium potassium tartrate (10 mL) was added, and the solvent removed. Water was added and the residue extracted with Et2O. The Et2O was washed with brine, dried and filtered. Removal of the solvent gave the title compound (1.204 g, 93%). 1H NMR (CDCl3) δ 13C NMR (CDCl3) δ 200.3, 155.5, 137.3, 136.6, 128.7, 128.1, 127.6, 127.0, 126.7, 122.1, 119.5, 119.0, 109.8, 109.1, 79.9, 60.2, 49.9, 28.3, 25.2,

Provenance & Evidence