反应详情

From 8-phenyloctanoic acid 71c and (RS)-5-(4-Benzyloxy-phenyl)-4-tertbutoxycarbonylamino-pent-2-enoic acid ethyl ester 77 (96% yield): 1H nmr (CDCl3) δ 1.20 (t, J=7.1 Hz, 3H), 1.27-1.55 (m, 10H), 2.06 (t, J=7.4 Hz, 2H), 2.52 (t, J=7.4 Hz, 2H), 2.74-2.79 (m, 2H), 4.10 (q, J=7.0 Hz, 2H), 4.84-4.88 (m, 1H), (4.94, s, 2H), 5.80 (br d, J=15.8 Hz, 1H), 6.00 (d J=8.2 Hz, 1H), 6.82-7.36 (m, 15H). 13C nmr (CDCl3) δ 172.5, 165.9, 157.5, 147.2, 142.5, 136.7, 130.1, 128.6, 128.3, 128.1, 128.0, 127.7, 127.2, 121.0, 114.7, 69.7, 60.2, 50.6, 39.3, 36.3, 35.7, 31.2, 29.0, 28.9, 28.1, 25.4, 14.0.