Hydrochloric Acid → HCID 69415564, compound

Participants

Reaction Steps

(RS)-5-(4-Benzyloxy-phenyl)-4-(7-phenyl-heptanoylamino)-pentanoic acid methyl ester 78 (872 mg, 1.74 mmol) was hydrogenated over 10% Pd—C in THF (20 mL) containing HCl solution (1 M, 2.5 mL). The solution was filtered (Celite™) and approximately two thirds of the solvent removed under reduced pressure. The solution was diluted with water and extracted into EtOAc. The combined extracts were washed with water, brine and dried with MgSO4. Evaporation of the solvent in vacuo afforded the title compound (702 mg, 98%). ESMS 412 (M+H)+.

Provenance & Evidence