Potassium Iodide → HCID 58930607, compound

Participants

Reaction Steps

To a solution of 18 (1.8 g, 8.71 mmol) in acetone (80 mL) were added 4-(2-chloroethyl)morpholine hydrochloride (1.95 g, 10.5 mmol), potassium iodide (360 mg, 2.2 mmol) and potassium carbonate (6.0 g, 44.0 mmol), respectively. The reaction mixture was refluxed for 16 h and concentrated. The residue was diluted with water and the aqueous phase was extracted twice with EtOAc. The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated to form a residue was purified by flash chromatography on silica gel (EtOAc/CH2Cl2, 50/50 to MeOH/CH2Cl2: 2/98) to afford the title compound 19 (2.7 g, 8.4 mmol, 96% yield).

Provenance & Evidence