HCID 58930642, compound → HCID 58930605, compound

HRID 852920Notes

Reaction equation

HRID 852920 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](=O)[NH:12][C:13]2[CH:18]=[C:17]([F:19])[C:16]([Cl:20])=[CH:15][C:14]=2[NH2:21])=[CH:6][CH:5]=1>CC(O)=O>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[NH:12][C:13]3[CH:18]=[C:17]([F:19])[C:16]([Cl:20])=[CH:15][C:14]=3[N:21]=2)=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 58930642HCID 58930642, compound

Product 1

HCID 58930605HCID 58930605, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Compound 72 (333 mg, 0.99 mmol) was dissolved in AcOH (10 ml) and the solution was refluxed, for 24 h. AcOH was evaporated and the residue was dissolved in AcOEt, washed with aqueous NH4Cl, NaHCO3 and brine, and dried over MgSO4 Evaporation of EtOAc provided the title compound 73 as a brownish powder (297 mg, 95%).

Workup

  1. temperaturethe solution was refluxed, for 24 h
  2. customAcOH was evaporated
  3. dissolutionthe residue was dissolved in AcOEt
  4. washwashed with aqueous NH4Cl, NaHCO3 and brine
  5. dry with materialdried over MgSO4 Evaporation of EtOAc

Sources & evidence

ORD record
ord-eb42bc5ea4fb409d83324f3b923d20bb
Source dataset
uspto-grants-2007_08
Patent number
US07253204B2

Reaction notes

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