Acetylpyrazine → N-(2-aminophenyl)-4-((4-(3-(hydroxymethyl)-5-methylisoxazol-4-yl)pyrimidin-2-ylamino)methyl)benzamide

Participants

Role	Name	HCID	Charge
Reactant	Acetylpyrazine	HCID 30914	—
Reactant	N-(2-aminophenyl)-4-((4-(pyrazin-2-yl)pyrimidin-2-ylamino)methyl)benzamide	HCID 44570891	—
Reactant	1-(3-(Hydroxymethyl)-5-methylisoxazol-4-yl)ethanone	HCID 45117985	—
Product	N-(2-aminophenyl)-4-((4-(3-(hydroxymethyl)-5-methylisoxazol-4-yl)pyrimidin-2-ylamino)methyl)benzamide	HCID 58930487	—

Reaction Steps

Title compound was obtained according to the scheme 6 similarly to the compound 26a (Example 29) using instead of 1-pyrazin-2-yl-ethanone as the starting material the ketone 324 (Table 11). Characterization of the title compound is provided in the Table 12.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07253204B2
Source dataset	uspto-grants-2007_08
ORD ID	ord-4ca2f3b676e944c2ab93df9f7f99d7f5
Source note	uspto-grants-2007_08