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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 852956생성일: 2026년 10월 25일

(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-one → 4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acid

https://huagongshe.com/reaction/852956

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참여 물질

역할이름HCID투입량
반응물(E)-3-(Dimethylamino)-1-(pyrazin-2-YL)prop-2-EN-1-oneHCID 5825354—
반응물(E)-1-[2-(Boc-Amino-)-4-methylthiazol-5-yl]-3-(dimethylamino)prop-2-en-1-oneHCID 58930506—
반응물4-[(4-Pyrazin-2-yl-pyrimidin-2-ylamino)-methyl]-benzoic acidHCID 66622167—
생성물4-((4-(2-(Tert-butoxycarbonylamino)-4-methylthiazol-5-yl)-pyrimidin-2-ylamino)methyl)benzoic acidHCID 5893047418%

반응 단계

Following the procedure described for the synthesis of the acid 25a (scheme 6, step 3) but substituting enamino ketone 23a for the enamino ketone 338, title compound was obtained in 18% yield and was used for the next steps without further purification. MS (m/z): 441.50 (calc) 442.3 (MH+) (found).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07253204B2
출처 데이터셋uspto-grants-2007_08
ORD IDord-e9a5801045ab4a7dadb599f28f457a1c
출처 메모uspto-grants-2007_08