HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-Fluorophenyl)cyclopropan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Carbamic acid, (2-(4-fluorophenyl)cyclopropyl)-, 1,1-dimethylethyl ester | HCID 58615363 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(4-Fluorophenyl)cyclopropan-1-amine | HCID 22174904 | — |
Reaction Steps
In a round flask was added [2-(4-fluoro-phenyl)-cyclopropyl]-carbamic acid tert-butyl ester (350 mg) and 4N HCl in 1,4-dioxane (3 mL) for 2 hours. The reaction mixture was concentrated by rotavaping to obtain the crude product of 270 mg as white solid. LC-MS m/e 152 (MH+). The crude product was directly used for next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253285B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-e13192096bad49ef9e8e840a3898f1dc |
| Source note | uspto-grants-2007_08 |