Sodium Acetate → HCID 178466911, compound

HRID 853029Notes

Reaction equation

HRID 853029 reaction equation
[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([CH:14]=O)[CH:12]=2)[N:7]=[CH:6][CH:5]=1)[CH3:2].[F:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]2[CH2:25][CH:24]2[NH:26][C:27]2[S:28][CH2:29][C:30](=[O:32])[N:31]=2)=[CH:19][CH:18]=1.C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH2:1]([O:3][C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11](/[CH:14]=[C:29]3/[C:30](=[O:32])[N:31]=[C:27]([NH:26][CH:24]4[CH2:25][CH:23]4[C:20]4[CH:21]=[CH:22][C:17]([F:16])=[CH:18][CH:19]=4)[S:28]/3)[CH:12]=2)[N:7]=[CH:6][CH:5]=1)[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 586153616-Quinolinecarboxaldehyde, 4-ethoxy-HCID 178516934HCID 178516934, compound

Product 1

HCID 178466911HCID 178466911, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The similar procedure as described in example 35 was used, starting with 4-ethoxy-quinoline-6-carbaldehyde (example 3b), 2-[2-(4-fluoro-phenyl)-cyclopropylamino]-thiazol-4-one, sodium acetate and acetic acid to give 5-[1-(4-ethoxy-quinolin-6-yl)-meth-(Z)-ylidene]-2-[2-(4-fluoro-phenyl)-cyclopropylamino]-thiazol-4-one. LC-MS m/e 434.5 (MH+).

Sources & evidence

ORD record
ord-ff44134db2f745878c6aad653951c73a
Source dataset
uspto-grants-2007_08
Patent number
US07253285B2

Reaction notes

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