HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Bromo-1H-indole-2-carboxylic acid ethyl ester → (R)-6-Bromo-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Bromo-1H-indole-2-carboxylic acid ethyl ester | HCID 7009496 | — |
| Reactant | (s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide | HCID 11195739 | — |
| Product | (R)-6-Bromo-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-indole-2-carboxylic acid ethyl ester | HCID 69415495 | — |
Reaction Steps
The title compound, ISP-MS: m/e=425.3, 427.3 (M+H+), was prepared in accordance with the general method of example 12b) from 6-bromo-1H-indole-2-carboxylic acid ethyl ester and (S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253281B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-c7e0ac44f2ae421e9f1ff008c0c41852 |
| Source note | uspto-grants-2007_08 |