HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-chloro-1H-indole-2-carboxylate → (r)-1-(2-Tert-butoxycarbonylamino-1-methyl-ethyl)-4-chloro-1h-indole-2-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-chloro-1H-indole-2-carboxylate | HCID 11075028 | — |
| Reactant | (s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide | HCID 11195739 | — |
| Product | (r)-1-(2-Tert-butoxycarbonylamino-1-methyl-ethyl)-4-chloro-1h-indole-2-carboxylic acid ethyl ester | HCID 69414316 | — |
Reaction Steps
The title compound, m.p.: 115–119° C., ISP-MS: m/e=381.3 (M+H+) and αD20=−8.0, was prepared in accordance with the general method of example 12b) from 4-chloro-1H-indole-2-carboxylic acid ethyl ester and (S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253281B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-68b3eba7136b49e7b692ba1ea0d0c83c |
| Source note | uspto-grants-2007_08 |