(s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide → HCID 69414673, compound

HRID 853060Notes

Reaction equation

HRID 853060 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[C:10]([Cl:16])[CH:9]=2)=[O:5])[CH3:2].[C:17]([O:21][C:22]([N:24]1[CH2:28][C@H:27]([CH3:29])OS1(=O)=O)=[O:23])([CH3:20])([CH3:19])[CH3:18]>>[CH2:1]([O:3][C:4]([C:6]1[N:7]([C@H:27]([CH3:29])[CH2:28][NH:24][C:22]([O:21][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:23])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([F:15])=[C:10]([Cl:16])[CH:9]=2)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 11195739(s)-Tert-butyl 5-methyl-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxideHCID 18986240HCID 18986240, compound

Product 1

HCID 69414673HCID 69414673, compound

Procedure

The title compound, ISP-MS: m/e=399.4 (M+H+), was prepared in accordance with the general method of example 12b) from 6-chloro-5-fluoro-1H-indole-2-carboxylic acid ethyl ester and (S)-5-methyl-2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester.

Sources & evidence

ORD record
ord-f74012270cd943e7bbc440a7eaac3cd4
Source dataset
uspto-grants-2007_08
Patent number
US07253281B2

Reaction notes

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