反应详情

温度

45 °C

NaOH (4.3 g, 107 mmol) was dissolved in ethanol (25 ml), and water (7 ml) was added thereto. Next, 2,2-dimethylpropionic acid 2-{[3-methoxy-4-(2-thiophene-2-ylvinyl)phenyl]methylamino}ethyl ester (4.0 g, 10.7 mmol) was dissolved in ethanol (8 ml) and added dropwise to the mixture. The mixture was stirred at room temperature for 2 hours and further at 45° C. for 1 hour. After the solvent was evaporated off, water (100 ml) was added and the oily matter was subjected to extraction with ethyl acetate. After 2 times of washing with water, drying over Na2SO4 and concentration were performed. The residue was purified by silica gel chromatography to give a yellow oily matter (yield: 3.1 g (100%)).

1. additionadded dropwise to the mixture
2. customAfter the solvent was evaporated off
3. additionwater (100 ml) was added
4. extractionthe oily matter was subjected to extraction with ethyl acetate
5. washAfter 2 times of washing with water
6. dry with materialdrying over Na2SO4 and concentration
7. customThe residue was purified by silica gel chromatography
8. customto give a yellow oily matter (yield: 3.1 g (100%))