Benzenesulfonyl chloride → HCID 178477576, compound

Participants

Reaction Steps

A solution of 0.71 g (1.87 mmol) of trans 4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-cyclohexylamine in 5 mL of CH2Cl2 was treated with 0.64 mL (3.74 mmol) of DIPEA and 0.24 mL (1.87 mmol) of benzenesulfonylchloride and stirred at RT for 3 hrs. Distribution of the crude mixture between a diluted aqueous solution of HCl and Et2O, drying of the combined organic phases over Na2SO4 and chromatography on silica gel with EtOAc/heptane 1:1 gave 0.9 g (93%) of trans-N-[4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-cyclohexyl]-benzenesulfonamide as a light yellow semisolid, MS: 518 (M−H).

Provenance & Evidence