Hydrochloric Acid → HCID 11704142, compound

Participants

Reaction Steps

A solution of 100 mg (0.37 mmol) of the acetate salt of 2-(4-amino-cyclohexyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol in 5 mL of DMF was treated with 0.2 mL (1.16 mmol) of DIPEA and 0.144 mL (1.1 mmol) of benzenesulfonyl chloride. The mixture was stirred for 1 hr and distributed between a diluted aqueous solution of HCl and Et2O. The combined organic phases were dried over Na2SO4 and the solvent was evaporated. Column chromatography on silica gel with EtOAc/heptane 1:1 gave 90 mg (72%) of N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethyl-ethyl)-cyclohexyl]-benzenesulfonamide as a pink solid, MS: 404 (M−H)−.

Provenance & Evidence