Iodoethane → HCID 178464527, compound

Participants

Reaction Steps

A solution of 150 mg (0.28 mmol) of trans 1,2-dimethyl-1H-imidazole-4-sulfonic acid [4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-cyclohexyl]-amide (example 9.1) in 1 mL of DMF was treated with 0.66 mL (0.44 mmol) of DBU, stirred for 15 min and treated with 0.9 mL (0.58 mmol) of ethyliodide. The mixture was stirred at 60° C. for 4 hrs and distributed between a saturated aqueous solution of NH4Cl and Et2O. Drying of the combined organic phases over Na2SO4 and evaporation of the solvent gave 150 mg (95%) of trans 1,2-dimethyl-1H-imidazole-4-sulfonic acid ethyl-[4-(2,2,2-trifluoro-1-triethylsilanyloxy-1-trifluoromethyl-ethyl)-cyclohexyl]-amide as a light yellow liquid, MS: 566 (M+H)+.

Provenance & Evidence