Hydrochloric Acid → HCID 69040619, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 500 mg of [4-(4-fluoro-benzyloxy)-phenoxy]-acetic acid ethyl ester in 10 ml of tetrahydrofurane was treated with 3.3 ml of sodium hydroxide solution (1 N). The mixture was heated at 50° C. for 2 h, then it was cooled to room temperature and 3.3 ml of hydrochloric acid (1 N) were added. While the tetrahydrofurane was evaporated under reduced pressure, the acid precipitated and, thereafter, was collected on a filter funnel. After washing with water and drying under reduced pressure, 376 mg of [4-(4-fluoro-benzyloxy)-phenoxy]-acetic acid was obtained, which was directly used for the further transformation.

Provenance & Evidence