HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-[4-(4-chloro-benzyloxy)-phenoxy]-N-methyl-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(Bromomethyl)-4-chlorobenzene | HCID 69329 | — |
| Reactant | 2-(4-hydroxyphenoxy)-N-methylacetamide | HCID 18183913 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-[4-(4-chloro-benzyloxy)-phenoxy]-N-methyl-acetamide | HCID 11536821 | — |
Reaction Steps
In analogy to the procedure described in Example 3 b), the alkylation of 2-(4-hydroxy-phenoxy)-N-methyl-acetamide [Example 3a)] with 1-bromomethyl-4-chloro-benzene in 2-butanone using potassium carbonate as the base yielded the 2-[4-(4-chloro-benzyloxy)-phenoxy]-N-methyl-acetamide as white crystals; MS: m/e=306 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07253318B2 |
| Source dataset | uspto-grants-2007_08 |
| ORD ID | ord-40aa36f1aab04b9fa0568df69d2cc5d6 |
| Source note | uspto-grants-2007_08 |